Endocrine Abstracts

Background: Different screening programs recommend starting active search for type 2 diabetes (DM2) at age from 35 to 45. This difference comes from variety in structure of population and weight of age as a risk factor, and also has economical background.The aim of our study: Was to find out the most acceptable cut–off age for DM2 screening in Uzbekistan.Material and Methods: We analyzed results of type 2 diabetes screening i...

Introduction: Graves’ disease (GD) is an autoimmune disorder of the thyroid gland, which is characterisied by a breakdown in immune tolerance. The lymphocytic infiltration of the thyroid leads to production of autioantibodies targeting thyroid stimulating hormone receptor (TSHR). The clinical course of GD varies among patients and it is difficult to predict the relapse risk after antithyroid therapy withdrawal. It is believed that GD occurs due to genetic suspectibility ...

Aim: To evaluate leptin and other adipocins content in the blood with type 2 diabetes.Materials and methods: Eighty six patients with type 2 diabetes were examined (59 women and 27 men) middle-aged 58.6±1.04 years old. The control group included 16 patients (eight women and eight men) middle-aged 22.6±0.6 years old. The HOMA-IR, insulin, adiponectin, resistin, leptin, and omentin levels were investigated.Results: In patie...

The enzyme dipeptidyl peptidase-IV (DPP-IV) is expressed by gut epithelial cells. DPP-IV cleaves X-proline dipeptides from the N-terminus of polypeptide hormones including GLP-1, GIP and PYY. DPP-IV causes a deactivation of the incretin hormones GLP-1 and GIP, whereas conversely, by converting PYY1–36 to PYY3–36 it allows specific activation of the Y2 receptors in the arcuate nucleus of the hypothalamus leading to hypophagia. Infused PYY3–36 has been ...

Carcinoid tumours are the commonest neuroendocrine tumours (50%), with a prevalence of 3–5/100,000. 10% present with carcinoid syndrome due to release of kinins and serotonin, released directly from the tumour in to the blood or due to liver metastases. Carcinoid heart disease due to ovarian carcinoid is extremely rare. Here we present such a case. A 69 year old female presented to surgeons with increased bowel frequency and weight loss. Blood tests, colonoscopy and biops...

We report a case of a female patient who presented aged 37yr with tiredness, weight gain and oligomenorrhea. Biochemically she was diagnosed with primary hypothyroidism with a TSH 10.9 mu/L and free-T4 8.2 pmol/L (10.5–22.0); she was commenced onto Thyroxine 50 mcg once a day (OD). Six months later her thyroid function tests improved with a TSH 2.2 mu/L and free-T4 13.0 pmol/L, however she felt her symptoms had worsened. The dose of thyroxine was increased to 75 mcg OD. ...

Introduction: In 2005, an explorative study was undertaken on behalf of the Pituitary Foundation (PF) to assess the psychosocial impact of living with a pituitary condition. The study found high levels of psychosocial distress among patients resulting in reduced quality of life (QoL). Improving QoL is central to the National Institute for Clinical Excellence guidance on improving outcomes for pituitary patients. The aim of this study was to utilise the same measures of psychos...

Introduction: Pituitary conditions are rare and diagnosis may be slow because symptoms are ambiguous. The treatment may be a combination of surgery, radiotherapy and medication so patients see many healthcare professionals. This survey sought to assess patient satisfaction with the information and support they receive from GPs, endocrinologists, neurosurgeons, radiotherapists, specialist nurses, and other agencies (e.g. Pituitary Foundation (PF)).Method:...

Normal ageing is accompanied by increased organismal frailty, reflecting organ specific functional decline, with an associated increase in the likelihood of disease. The immune system undergoes significant decline with age, termed immunesenescence, which results in increased susceptibility to infection and reduced vaccination responses. Significant changes in the hormonal milieu also occur with age and it is clear that age-related changes in adrenal hormone secretion can impos...

We evaluated the volume of pituitary adenoma in patients treated with ocreotide LAR (SSLAR) prior to surgery.Materials and methods: Twenty-six patients (22 females and 4 males, mean age 57.5±15.0 years) were treated with SSLAR: 5 patients with microadenoma – during 6 months, and 21 patients with macroadenoma – during 12 months before surgery, as recommended by the Polish Society of Endocrinology. Concentration of hGH and IGF1 was evaluated...